TikTok Shop now accounts for nearly 20% of all social commerce sales in 2025. The platform’s blend of short-form entertainment and integrated shopping means viral content can translate directly into product sales. A single TikTok video on the “For You” feed can spark thousands of orders overnight, especially under TikTok’s affiliate model where creators promote products for a commission.
For Direct-to-Consumer (DTC) and Consumer Packaged Goods (CPG) brands, leveraging this creator-driven approach offers enormous brand awareness and measurable conversion uplift.
Here are the 10 top U.S.-based agencies that help brands harness TikTok’s potential through savvy advertising and affiliate-driven campaigns.
10 TikTok Marketing Agencies
Uptickk
Uptickk is a TikTok-first agency specializing in TikTok Shop management, creator partnerships, and affiliate campaigns. As one of TikTok’s initial beta partner agencies, Uptickk brings deep expertise in setting up and optimizing TikTok Shops. The team manages influencer and affiliate programs that help brands go viral through native-feeling content and commission-based incentives. Uptickk is an Official TikTok Marketing Partner and proudly manages 2 of the top 10 TikTok Shops on the platform, driving record-breaking growth for DTC brands. With data-driven ad strategies and end-to-end shop management, Uptickk has positioned itself as a leader in turning TikTok content into real revenue.
Avenue Z
Avenue Z is an official TikTok Shop Partner (and Shopify Plus partner) known for building full-funnel TikTok commerce ecosystems. They handle everything from TikTok Shop setup and affiliate marketing programs to influencer partnerships and paid TikTok ads. Avenue Z’s results speak volumes – for example, they helped the brand Yogibo boost TikTok Shop sales by 500% in just a few weeks. The agency even acquired The Snow Agency (a firm that drove $1B+ revenue for 200+ DTC brands) to bolster its social commerce expertise. For DTC and CPG brands ready to go all-in on TikTok, Avenue Z provides the technical setup, creator network, and growth strategy needed to turn TikTok into a major revenue driver.
Skale Strategy
Skale Strategy is a Utah-based e-commerce marketing agency originally renowned for its Amazon services, which has now expanded into TikTok Shop management and affiliate marketing for DTC brands. Skale offers a holistic approach – their team helps with everything from Amazon and Walmart marketplaces to emerging channels like TikTok Shop, all under one roof. In practice, this means a brand working with Skale can get its Amazon listings optimized and its TikTok affiliate campaigns running in parallel, ensuring consistency and creative strategy across platforms. Skale’s foray into TikTok focuses on connecting brands with on-trend creators and managing commission-based affiliate programs (leveraging their Amazon know-how in data and conversion optimization). This omnichannel capability keeps sellers competitive as platforms evolve. For brands seeking a single partner to manage both marketplace ops and TikTok social commerce, Skale Strategy is a compelling option.
MuteSix
MuteSix (also known as M6) is a large digital marketing agency that was on TikTok Shop from the very beginning. They mastered TikTok’s social commerce offerings early, making them a go-to for brands integrating TikTok into their performance marketing mix. MuteSix offers creative production, media buying, and analytics – and crucially, they know how to turn TikTok views into sales. In fact, their TikTok Shop campaigns have increased clients’ sales by up to 976% in some cases. Top DTC brands like Farmacy and Pinsy trust MuteSix to blend influencer-driven content with paid TikTok ads, yielding high ROI and new customer acquisition through the platform.
AdQuadrant
AdQuadrant is a certified TikTok Shop Preferred Partner focused on helping DTC brands scale via TikTok. This agency excels at both organic TikTok strategy and paid social campaigns, often tailoring efforts to products ranging from beauty to home goods. AdQuadrant’s emphasis on social commerce performance is backed by case studies – for example, one TikTok campaign beat industry benchmarks by 30% in ROI. They leverage influencer content, TikTok Shop optimizations, and precise ad targeting to drive conversions. With big-name clients like Stella & Dot and Aventon in their portfolio, AdQuadrant has a proven track record of turning TikTok trends into sustained sales growth.
Upfluence
Upfluence stands out as a hybrid influencer marketing platform + agency that is highly geared toward TikTok affiliate commerce. Integrated with TikTok Shop, Upfluence enables brands to recruit a massive network of creators and track sales driven by each creator in real time. This data-driven approach means brands can identify which influencers actually convert viewers into buyers, not just rack up views. Upfluence’s tools cover influencer discovery, campaign management, and performance analytics, giving DTC brands a scalable way to run TikTok affiliate programs. It’s an ideal partner for companies looking to build a strong, ongoing community of TikTok affiliates (versus one-off sponsored posts) to fuel consistent social commerce growth.
The Influencer Marketing Factory
The Influencer Marketing Factory is a Miami-based international agency that connects brands with Gen Z and Millennial consumers through TikTok. This agency combines creative storytelling with a conversion-focused TikTok Shop strategy, ensuring that influencer content isn’t just engaging but also drives purchases. They emphasize transparency and data: campaigns are guided by analytics to deliver predictable outcomes for brands. The Influencer Marketing Factory has run global campaigns (for brands like Dunkin’ and FOREO) that boost follower counts and generate viral engagement. For DTC and CPG companies seeking both brand awareness and sales via TikTok, this agency offers deep expertise in blending influencer narratives with direct-response marketing on the platform.
Tinuiti
Tinuiti is one of the largest independent performance marketing agencies in the U.S., and it’s a certified TikTok Shop Partner with enterprise-level capabilities. Tinuiti enjoys exclusive early access to new TikTok ad features and beta programs, giving its clients an edge on the platform. The agency takes a full-funnel approach: they blend e-commerce expertise, social media strategy, and influencer marketing into cohesive TikTok campaigns that drive awareness at the top and conversions at the bottom. Notably, Tinuiti’s client roster includes major CPG and retail brands like e.l.f. Cosmetics, Liquid I.V., and Poppi, who have all seen success on TikTok Shop. For brands with aggressive growth goals (and larger budgets), Tinuiti provides advanced tools, dedicated account teams, and multi-channel knowledge (spanning Amazon, Meta, Google, and more) to scale on TikTok.
Blue Wheel Media
Blue Wheel Media is a TikTok Agency Partner known for comprehensive end-to-end TikTok Shop management. They handle everything from product listing optimization and Shop setup to managing a large volume of creator-led video campaigns. Blue Wheel’s performance-focused approach has yielded impressive results – for instance, one CPG snack brand (IQBar) saw a 722% increase in revenue after Blue Wheel helped it expand onto TikTok Shop. The agency’s strength lies in marrying TikTok with other channels: Blue Wheel often pairs TikTok influencer content with paid ads and even supports cross-channel efforts on Google, Bing, Amazon, and email. This makes them especially powerful for brands that sell on Amazon or multi-channel retailers, as they ensure TikTok campaigns drive conversion lift across the board. Blue Wheel’s track record (managing $1B+ in ecommerce revenue) and expertise in CPG social commerce make them a top choice for scaling on TikTok.
Ubiquitous
Ubiquitous is a specialized TikTok influencer marketing agency that operates at massive scale. With one of the largest networks of TikTok creators in the industry, Ubiquitous excels in high-volume, fast-turnaround campaigns. Their approach is all about affiliate seeding: they can activate hundreds of micro- and macro-creators to promote a product simultaneously, flooding TikTok with genuine UGC content and tracking performance closely. This volume-driven strategy is highly effective for brand awareness – and because creators are typically paid on performance (commission or results-based), it drives conversion efficiently as well. Ubiquitous is ideal for DTC brands that want to scale up quickly on TikTok by getting tons of authentic content and letting TikTok’s algorithm find the winning posts. In short, they leverage quantity and data to identify which creators and content generate sales, then double down on those for explosive social commerce growth.
Conclusion
TikTok’s creator-fueled model of commerce is transforming how brands reach and convert audiences. With TikTok Shop on track to exceed $20 billion in sales in 2026, savvy brands are partnering with agencies like the ones above to navigate this fast-paced landscape. By blending influencer creativity with performance marketing and affiliate incentives, these agencies help DTC and CPG companies turn TikTok’s virality into real ROI. As social commerce continues its rise (expected to top $100B in the U.S. by 2026), tapping into TikTok through the right agency can be a game-changer – delivering both instant brand buzz and sustainable sales growth. Each of these top agencies offers a slightly different formula, but all share a common goal: to help brands dominate TikTok and ride the social commerce wave that’s defining retail now.
